Can You Stop GLP-1 Therapy After Losing Weight?

GLP-1 receptor agonists have helped many people achieve significant weight loss by reducing appetite and supporting healthier eating patterns. But once you reach your goal weight, an important question arises: can you stop GLP-1 therapy and keep the weight off, or will discontinuation undo your progress? Affinity Urgent Care explains what to consider before stopping, tapering, or continuing GLP-1 medications.

Stopping GLP-1 After Weight Loss

Reaching a healthy weight is a major accomplishment, but GLP-1 therapy only helps manage the biological factors that contribute to weight gain. If the medication is stopped, its effects, such as reduced hunger, may fade, making weight maintenance more challenging. Keeping the weight off after discontinuing GLP-1 therapy requires a detailed plan. This may include the following:

• Eating balanced meals with lean proteins, high-fiber vegetables, and whole grains

• Staying active with regular exercise

• Prioritizing quality sleep

• Managing stress

For some patients, ongoing medical supervision may be needed to maintain weight and health markers.

Why People Discontinue GLP-1 Therapy

Long-term use of GLP-1 receptor agonists is considered generally safe and beneficial for most patients. These medications improve weight control, cardiovascular health, and blood sugar regulation. However, side effects like nausea, digestive discomfort, or cost may influence the decision to stop.

Considerations for Stopping GLP-1 Therapy

You can stop GLP-1 therapy after losing weight, but this choice depends on your medical history, goals, and ability to sustain healthy habits without medication. For some, the benefits of ongoing treatment outweigh the drawbacks. Factors to consider before discontinuing treatment include:

• An increase in hunger hormones – When GLP-1 medication leaves your system, your body’s natural hunger hormones, such as ghrelin, return. This can make it easier to overeat or return to old habits. Research shows that some people regain a portion of the weight they lost within months after discontinuing GLP-1. Without a maintenance plan, the risk of gaining weight is higher.

• Weight rebound – The risk of weight rebound after stopping GLP-1 therapy is one reason many healthcare providers see these medications as part of a long-term strategy. For some patients, staying on a lower dose may be the best way to maintain results.

While it’s not inevitable, research shows that without continued medical or lifestyle support, many people regain part or all of their lost weight. This highlights the importance of having a structured plan in place. The best approach is to work closely with a health care provider who can guide you through the transition, minimize weight regain, and protect your overall health.

Weaning Off GLP-1 Therapy

Most people can stop GLP-1 receptor agonists under medical guidance. Some people stop GLP-1 medication suddenly, but others benefit from a gradual taper. Slowly lowering the dose gives your body time to adjust as appetite and hunger signals change. Here are some steps your provider may take when discontinuing GLP-1:

• Gradual dose reduction

• Frequent follow-up visits to track weight, blood pressure, and other health markers

• Nutrition and exercise guidance

Your health care provider can monitor your progress to help reduce the risk of weight regain.

Post-GLP-1 Weight Management Strategies

Once you stop GLP-1 therapy, the focus should be on maintaining sustainable health habits, such as:

• Choosing nutritious foods that keep you full and energized

• Combining cardio and strength training to support metabolism

• Monitoring weight and health markers with routine checkups

• Considering behavioral support, counseling, support groups, or health coaching  

Personalizing these steps to your lifestyle and needs is the best way to prevent weight gain.  

Reach Out To Learn More

Affinity Urgent Care offers guidance for patients considering starting, continuing, or stopping GLP-1 therapy. If you’re considering this option, please reach out to learn more about GLP-1 and weight loss maintenance. Serving the communities of La Marque, Galveston, and Alvin, Texas, we prioritize your health and well-being.